Glyphosate Causes Irreversible Abnormal Growth & Delayed Development of Embryonic Rat Neuronal Cells

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ISIS Report 20/01/16
Glyphosate Causes Irreversible Abnormal Growth & Delayed Development of Embryonic Rat Neuronal Cells
Primary rat neuronal cultures exposed to glyphosate showed abnormal morphology, delayed differentiation and decreased activity of a Wnt signalling pathway involved in embryonic development Dr Eva Sirinathsinghji
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A new study finds that cultured embryonic rat neurones exposed to sub-lethal doses of glyphosate show a delay in development characterised by reduced neuronal polarisation, complexity and morphology.  Underlying the abnormalities was reduced activity of a Wnt protein Wnt5a, a signalling transduction molecule, as well as its downstream signalling effector CaMKII (Ca2+/calmodulin-dependent protein kinase II). Effects of glyphosate were rescued through the restoration of normal Wnt signalling activity, validating its involvement in glyphosate?s neurotoxic effects.

The toxicity of glyphosate herbicides and their formulation products are widely recognised in the scientific literature, with evidence accumulating on its neurotoxic effects (see [1] Banishing Glyphosate, Special ISIS report). Studies have linked glyphosate to Parkinson?s disease following acute exposure, increased seizures in epileptic patients, and deficits in learning and memory; and there is epidemiological evidence of increased behavioural problems in children such as ADHD (see [1]). Further, a recent investigation into neurotoxic mechanisms identified increased oxidative stress and cell death in the hippocampus of exposed rats linked to increased levels of extracellular glutamate neurotransmitter [2]. Nevertheless, cellular mechanisms underlying nervous system damage remained unknown.

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URGENT farmers demo in Poland

Dear ALL,

We need an international support to a growing farmers demo… now in 4 cities in Poland. Its a vital one: Polish farm land is being sold to foreign multinationals through the exploitation of a loophole in the law. Farmers are rightly angry and are blocking the roads and admin centres associated with this scam. They are also demonstrating for the right to sell their food locally and to block GMO.

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International Resistance to the the Modification and Control of Life

– Julian Rose –

Resistance comes in three shades: passive, occasionally active and active.
The corporate and political powers who aim to take a controlling influence over the food chain count on the majority of civil resistance being of a passive ‘dumbed down’ nature. They can tolerate a certain amount of ‘occasionally active’ interference in their master plan, but they do not tolerate genuinely active resistance. So those of us who hammer continuously on genetically modified corporate doors are monitored, harassed and generally marginalised by the prevailing ’status quo’ and its media poodles.

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