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ISIS Report 20/01/16
Glyphosate Causes Irreversible Abnormal Growth & Delayed Development of Embryonic Rat Neuronal Cells
Primary rat neuronal cultures exposed to glyphosate showed abnormal morphology, delayed differentiation and decreased activity of a Wnt signalling pathway involved in embryonic development Dr Eva Sirinathsinghji
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A new study finds that cultured embryonic rat neurones exposed to sub-lethal doses of glyphosate show a delay in development characterised by reduced neuronal polarisation, complexity and morphology. Underlying the abnormalities was reduced activity of a Wnt protein Wnt5a, a signalling transduction molecule, as well as its downstream signalling effector CaMKII (Ca2+/calmodulin-dependent protein kinase II). Effects of glyphosate were rescued through the restoration of normal Wnt signalling activity, validating its involvement in glyphosate?s neurotoxic effects.
The toxicity of glyphosate herbicides and their formulation products are widely recognised in the scientific literature, with evidence accumulating on its neurotoxic effects (see  Banishing Glyphosate, Special ISIS report). Studies have linked glyphosate to Parkinson?s disease following acute exposure, increased seizures in epileptic patients, and deficits in learning and memory; and there is epidemiological evidence of increased behavioural problems in children such as ADHD (see ). Further, a recent investigation into neurotoxic mechanisms identified increased oxidative stress and cell death in the hippocampus of exposed rats linked to increased levels of extracellular glutamate neurotransmitter . Nevertheless, cellular mechanisms underlying nervous system damage remained unknown.Read more